There are currently 6 confirmed cases of Hand, Foot and Mouth Disease (HFMD) in Phoenix, Durban.
EThekwini Municipality said on Friday afternoon, people should remain calm.
The cases reported, are among learners in grade 1, 2, and 3, all under the age of 10.
The City said its Area Based Outbreak Response Team, has investigated and is closely monitoring the situation.
HFMD is a common illness affecting infants and young children, often occurring in small outbreaks during summer and autumn.
It should not be confused with Foot and Mouth Disease, which affects animals.
HFMD is a highly contagious viral infection which spreads through contact with the mouth, nose, and eyes.
Symptoms typically appear between three to six days after exposure and last for seven to 10 days.
As a result, the City has advised parents to visit the nearest clinic if their children show symptoms.